منابع مشابه
Weighing up a seven-year period
At the end of my term of office as Editor-in-Chief of Acta Otorhinolaryngologica Italica, i should like to briefly recall some of the results achieved. The principal aim indicated by the Board of the italian Society of otorhinolaryngology – head and neck Surgery (Sio) was to work towards the journal which had then only recently been published in English under the Editor-in-Chief, at that time D...
متن کاملMortality and causes of death in females with extra X chromosomes and males with extra Y chromosomes.
A prospective study of mortality in females with extra X chromosomes and males with extra Y chromosomes is reported. Among the 94 females who survived infancy and were then observed on average for 16 years there were 24 deaths compared with an expected mortality of 10.7. The greater than twofold increase is highly significant (p less than 0.005). The deaths were due to a variety of diseases but...
متن کاملChromosome Structure: Coiling up chromosomes
The mechanism by which eukaryotic chromosomes condense as cells enter mitosis has long been inaccessible to molecular biologists. An important clue has now been provided by a ubiquitous protein family, the SMCs.
متن کاملThe tolerance of extra chromosomes by primitive tomatoes.
T H E unexpected composition of the progeny of a triploid plant of the Red Cherry variety of tomato (Lycopersicon esculentum) attracted our attention to the possibilities of greater tolerance of aneuploidy in primitive than in highly selected horticultural varieties. Previous experience with the latter varieties revealed striking morphological manifestations, reduced vigor, and decreased fertil...
متن کاملThe presence of extra chromosomes leads to genomic instability.
Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe developmental defects, yet the molecular mechanisms explaining its effects on cellular physiology remain elusive. Here we show, using a series of human cells with defined aneuploid karyotypes, that gain of a single chromosome increases genomic instability. Next-generation sequencing and SNP-array analysis...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2020
ISSN: 1474-175X,1474-1768
DOI: 10.1038/s41568-020-0257-y